Price observed over the last 3 months for a round trip.
Compare all flight tickets and find cheap flights from Des Moines to St Louis
The cheapest flights right now
Des Moines – St Louis
Outbound – Nov 23, 2026
1 stop
3h 25m MDW
Return – Dec 2, 2026
1 stop
5h 5m MDW
$315
yesterday
Des Moines – St Louis
Outbound – Nov 23, 2026
1 stop
4h 40m MDW
Return – Dec 2, 2026
1 stop
6h 15m DEN
$251
yesterday
* Prices are in USD per passenger, including taxes, for a round trip. Prices are based on searches carried out within the last 72 hours. Please note that availability and ticket prices are subject to change and should not be considered as the final price quoted.
Cheapest flight tickets
$337
Average price of a round trip
$392
Average flight ticket price recorded over the last 3 months for a round trip.
Flight duration
22h36
A flight from Des Moines to St Louis takes on average 22h36.
Best time
September
According to user searches, the ideal month to go to St Louis is September.
Price of flight tickets from Des Moines to St Louis
Here is some information and tips to know before booking your flight:
- Flight ticket prices range from $337 to $412
- The average price of a flight ticket is about $392
- Prices are lowest for stays in the month of October
- The month in which booking a ticket is cheaper is: September
info departure city :
Des Moines, USA
airports :
Des Moines International Airport (DSM)
Ankeny Regional Airport (IKV)
local time :
Des Moines is a city in the country USA, the time zone is [[timezone]]. In Des Moines, it is currently {fromLocalTime}, the temperature is on average 12°C, with a minimum of 7°C and a maximum of 19°C.
The city of Des Moines has 2 airport(s): Des Moines and Ankeny
destination info :
St Louis, USA
airports :
Lambert-St. Louis International Airport (STL)
St. Louis Downtown Airport (CPS)
Spirit of St. Louis Airport (SUS)
local time :
St Louis is in the country USA, the time zone is [[timezone]]. In St Louis, it is currently {toLocalTime}, the temperature is on average 16°C, with a minimum of 10°C and a maximum of 22°C.
The city of St Louis has 3 airport(s): Lambert-St. Louis, St. Louis Downtown and Spirit of St. Louis
Useful info about St Louis
What is the least touristic period to go to St Louis?
If you want to visit St Louis during the least touristic period, choose the month of September.
What is the most popular time to travel to St Louis?
In St Louis, the most popular month is October. It is during this period that the prices offered by airlines are also the highest.
When should I book my flight from Des Moines to St Louis?
According to our data, it is recommended to book your flight 14 days before your departure. If you book your flight ticket 3 weeks before your departure, you may find a price below average. You can also choose morning flights that are 100% cheaper than afternoon and evening flights. The cheapest day to book a flight from Des Moines to St Louis is Saturday.
What are the arrival and destination airports when traveling between Des Moines and St Louis?
When you leave, you can leave from Des Moines, and you will arrive at Lambert-St. Louis.
How to reach Des Moines airport from the city centre?
The airport Des Moines is located 8 km or Ankeny is located 10 km from the city centre. You can access it by using public transportation, taking a taxi, or renting a car.
Are there other means of transportation to go from Des Moines to St Louis?
Airplane is the only means of transportation listed on Liligo for this journey.
Are there big differences in weather between Des Moines and St Louis?
In summer, the average temperature is 25°C in St Louis and 23°C in Des Moines. The average rainfall in summer is 135 mm in St Louis and 131 mm in Des Moines. In summer, it is warmer in St Louis and it rains less in Des Moines. In winter, it is colder in St Louis and it rains more in St Louis.
